Latest Commentaries

Volume 430

Light on fluorescent lipids in rafts: a lesson from model membranes

N. Kahya..........e7‑e9

Published on the Internet 27 August 2010, doi:10.1042/BJ20101196

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14-3-3 proteins are promising LRRK2 interactors

I. N. Rudenko and M. R. Cookson..........e5‑e6

Published on the Internet 27 August 2010, doi:10.1042/BJ20101200

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Adipose tissue inflammation and insulin resistance: all obese humans are not created equal

M.‑S. Gauthier and N. B. Ruderman..........e1‑e4

Published on the Internet 13 August 2010, doi:10.1042/BJ20101062

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Volume 428

ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding?

R. Bass and D. R. Edwards..........e3‑e5

Published on the Internet 27 May 2010, doi:10.1042/BJ20100568

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New methods for capturing the mystery lipid, PtdIns5P

J. M. Backer..........e1‑e2

Published on the Internet 27 May 2010, doi:10.1042/BJ20100688

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Volume 427

Molecular insights into mechanisms of intramembrane proteolysis through signal peptide peptidase (SPP)

B. Schröder and P. Saftig..........e1‑e3

Published on the Internet 14 April 2010, doi:10.1042/BJ20100391

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Volume 426

Frataxin, a molecule of mystery: trading stability for function in its iron-binding site

D. J. R. Lane and D. R. Richardson..........e1‑e3

Published on the Internet 9 February 2010, doi:10.1042/BJ20091959

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Volume 425

Caught in the middle: the role of Bag3 in disease

A. K. McCollum, G. Casagrande and E. C. Kohn..........e1‑e3

Published on the Internet 14 December 2009, doi:10.1042/BJ20091739

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Volume 424

Biomembrane liquid–liquid phase separation and detergent resistance: a relationship strengthened

D. Holowka..........e5‑e6

Published on the Internet 11 November 2009, doi:10.1042/BJ20091623

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New biochemical approaches towards understanding the Parkinson's disease-associated kinase, LRRK2

G.‑Y. Liou and K. A. Gallo..........e1‑e3

Published on the Internet 23 October 2009, doi:10.1042/BJ20091540

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Volume 423

Why do phosphatidylinositol kinases have so many isoforms?

S. H. Min and C. S. Abrams..........e5‑e8

Published on the Internet 14 September 2009, doi:10.1042/BJ20091274

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Novel compound with potential of an antibacterial drug targets FtsZ protein

D. Dasgupta..........e1‑e3

Published on the Internet 14 September 2009, doi:10.1042/BJ20091226

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Volume 422

Fishing in the (deoxyribonucleotide) pool

A. Saada..........e3‑e6

Published as BJ Immediate Publication 27 August 2009, doi:10.1042/BJ20091194

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Oxidation of methionine residues: the missing link between stress and signalling responses in plants

M. J. Emes..........e1‑e2

Published on the Internet 13 August 2009, doi:10.1042/BJ20091063

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Volume 421

Pancreatic stellate cells can form new β-like cells

K. Docherty..........e1‑e4

Published on the Internet 26 June 2009, doi:10.1042/BJ20090779

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Volume 420

How essential is cholesterol?

J. Stevenson and A. J. Brown..........e1‑e4

Published on the Internet 13 May 2009, doi:10.1042/BJ20090445

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Volume 419

Drug screening by crossing membranes: a novel approach to identification of trypanocides

M. C. Field..........e1–e3

Published on the Internet 27 March 2009, doi:10.1042/BJ20090283

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Volume 418

A role for the syntaxin N-terminus

M. Munson and N.J. Bryant..........e1–e3

Published on the Internet 28 January 2009, doi:10.1042/BJ20082389 (see accompanying paper, pp. 73–80)

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Volume 417

A traffic signal for heterodimeric amino acid transporters to transfer from the ER to the Golgi

V. Ganapathy..........e9–e11

Published on the Internet 23 December 2008, doi:10.1042/BJ20082246 (see accompanying paper, pp. 441–448)

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New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

C. Peifer and D.R. Alessi..........e5–e7

Published on the Internet 12 December 2008, doi:10.1042/BJ20082243 (see accompanying paper, pp. 361–370)

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Inhibitors of apoptosis catch ubiquitin

K. Rajalingam and I. Dikic..........e1–e3

Published on the Internet 12 December 2008, doi:10.1042/BJ20082215 (see accompanying paper, pp. 149–160)

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Volume 416

mTORC2 is the hydrophobic motif kinase for SGK1

L. Yan, V. Mieulet and R.F. Lamb..........e19–e21

Published on the Internet 26 November 2008, doi:10.1042/BJ20082202 (see accompanying paper, pp. 375–385)

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Viral hepatitis and fatty liver disease: how an unwelcome guest makes pâté of the host

A.J. Brown..........e15–e17

Published on the Internet 12 November 2008, doi:10.1042/BJ20081916

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Wnt signalling at the crossroads of nutritional regulation

J.K. Sethi and A.J. Vidal-Puig..........e11–e13

Published on the Internet 12 November 2008, doi:10.1042/BJ20082074

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Adiponectin: no longer the lone soul in the fight against insulin resistance?

K.E. Davis and P.E. Scherer..........e7–e9

Published on the Internet 12 November 2008, doi:10.1042/BJ20082033

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PPR (pentatricopeptide repeat) proteins in mammals: important aids to mitochondrial gene expression

R.N. Lightowlers and Z.M.A. Chrzanowska-Lightowlers..........e5–e6

Published on the Internet 28 October 2008, doi:10.1042/BJ20081942 (see accompanying paper, pp. 15–26)

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LKB1: cancer, polarity, metabolism, and now fertility

R.J. Shaw..........e1–e3

Published on the Internet 28 October 2008, doi:10.1042/BJ20082023 (see accompanying paper, pp. 1–14)

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Volume 415

Sorting out PtdIns(4,5)P₂ and clathrin-coated vesicles in plants

C. Brearley..........e1–e3

Published on the Internet 15 October 2008, doi:10.1042/BJ20081830 (see accompanying paper, pp. 387–399)

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Volume 414

Arfs and membrane lipids: sensing, generating and responding to membrane curvature

J.G. Donaldson..........e1–e2

Published on the Internet 12 August 2008, doi:10.1042/BJ20081438 (see accompanying paper, pp. 189–194)

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Volume 413

CD95 ligation and intracellular membrane flow

R. Reinehr and D. Häussinger..........e11–e12

Published on the Internet 15 July 2008, doi:10.1042/BJ20081094 (see accompanying paper, pp. 467–478)

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Phosphorylation of Argonaute proteins: regulating gene regulators

S. Rüdel and G. Meister..........e7–e9

Published on the Internet 15 July 2008, doi:10.1042/BJ20081244 (see accompanying paper, pp. 429–436)

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Investigating lipid signalling: it's all about finding the right Pl

E. Nielsen..........e5–e6

Published on the Internet 12 June 2008, doi:10.1042/BJ20080953 (see accompanying paper, pp. 115–124)

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β-Arrestin multimers: does a crowd help or hinder function?

K.A. DeFea..........e1–e3

Published on the Internet 12 June 2008, doi:10.1042/BJ20081009 (see accompanying paper, pp. 51–60)

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Volume 412

The cross-talk between NFκB and HIF-1: further evidence for a significant liaison

A. Görlach and S. Bonello..........e17–e19

Published on the Internet 28 May 2008, doi:10.1042/BJ20080920 (see accompanying paper, pp. 477–484)

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AMPK, MAPK and Bax in the heart: some questions answered

V. Borutaite..........e15–e16

Published on the Internet 14 May 2008, doi:10.1042/BJ20080712

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S-Nitrosation and thiol switching in the mitochondrion: a new paradigm for cardioprotection in ischaemic preconditioning

B.G. Hill and V.M. Darley-Usmar..........e11–e13

Published on the Internet 14 May 2008, doi:10.1042/BJ20080716

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Opioid and chemokine receptor heterodimers: arranged marriages or dangerous liaisons?

T.E. Hébert..........e7–e9

Published on the Internet 14 May 2008, doi:10.1042/BJ20080620 (see accompanying paper, pp. 245–256)

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Cancer therapy: staying current with AMPK

D.A. Fruman and A.L. Edinger..........e3–e5

Published on the Internet 14 May 2008, doi:10.1042/BJ20080823 (see accompanying paper, pp. 211–221)

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Trehalose 6-phosphate: a signal of sucrose status

M.J. Paul..........e1–e2

Published on the Internet 25 April 2008, doi:10.1042/BJ20080598

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Volume 411

New insights into PKC family affairs: three novel phosphorylation sites in PKCe and at least one is regulated by PKCa

C. Larsson..........e15–e16

Published on the Internet 27 March 2008, doi:10.1042/BJ20080373 (see accompanying, paper pp. 319–331)

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Where in the cell is SIRT3? – functional localization of an NAD⁺-dependent protein deacetylase

W.C. Hallows, B.N. Albaugh and J.M. Denu..........e11–e13

Published on the Internet 27 March 2008, doi:10.1042/BJ20080336 (see accompanying paper, pp. 279–285)

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Regulation of the AMPK-related protein kinases by ubiquitination

D.M. Thomson, M.D.H. Hansen and W.W. Winder..........e9–e10

Published on the Internet 27 March 2008, doi:10.1042/BJ20080459 (see accompanying paper, pp. 249–260)

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Transcription factors that behave as master regulators during mammalian embryogenesis function as molecular rheostats

A. Rizzino..........e5–e7

Published on the Internet 27 March 2008, doi:10.1042/BJ20080479 (see accompanying paper, pp. 227–231)

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Ca²⁺ signalling: a new route to NAADP

G.A. Rutter and E.A. Bellomo..........e1–e3

Published on the Internet 13 March 2008, doi:10.1042/BJ20080282 (see accompanying paper, pp. 63–70)

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Volume 410

Calcium-dependent Pyk2 activation: a role for calmodulin?

M.D. Schaller..........e3–e4

Published on the Internet 27 February 2008, doi:10.1042/BJ20080133 (see accompanying paper, pp. 513–523)

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The LEA proteins and trehalose loving couple: a step forward in anhydrobiotic engineering

G. Iturriaga..........e1–e2

Published on the Internet 12 February 2008, doi:10.1042/BJ20071633

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Volume 409

An alternatively spliced exon links intermediate filaments to adhesions

M. Gimona..........e1–e2

Published on the Internet 15 January 2008, doi:10.1042/BJ20071674 (see accompanying paper, pp. 657–667)

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Volume 408

Enzyme substrate recognition in oxygen sensing: how the HIF trap snaps

E. Metzen..........e5–e6

Published on the Internet 14 November 2007, doi:10.1042/BJ20071306 (see accompanying paper, pp. 231–240)

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A role for NPC1 and NPC2 in intestinal cholesterol absorption – the hypothesis gutted

L. Liscum..........e1–e3

Published on the Internet 29 October 2007, doi:10.1042/BJ20071340 (see accompanying paper, pp. 1–5)

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Volume 407

Finding the needles in the haystack: mapping constitutive proteolytic events in vivo

M. Bogyo..........e1–e3

Published on the Internet 12 September 2007, doi:10.1042/BJ20071096 (see accompanying paper, pp. 41–48)

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Volume 406

Pharmacological chaperoning: two ‘hits’ are better than one

W.R. Skach..........e1–e2

Published on the Internet 13 August 2007, doi:10.1042/BJ20070896 (see accompanying paper, pp. 257–263)

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Volume 405

MAPK activation by radio waves

J.S.C. Arthur..........e5–e6

Published on the Internet 13 July 2007, doi:10.1042/BJ20070762 (see accompanying paper pp. 559–568)

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Evidence for oxygen as the master regulator of the responsiveness of soluble guanylate cyclase and cytochrome c oxidase to nitric oxide

A. Landar and V.M. Darley-Usmar..........e3–e4

Published on the Internet 27 June 2007, doi:10.1042/BJ20070590 (see accompanying paper pp. 223–231)

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Caspase-9 cleavage: do you need it?

D. Twiddy and K. Cain..........e1–e2

Published on the Internet 13 June 2007, doi:10.1042/BJ20070617 (see accompanying paper pp. 11–19

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Volume 404

Collagen pretzels revealed by electron microscopy

K. Kadler..........e7–e8

Published on the Internet 29 May 2007, doi:10.1042/BJ20070416

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Testing the adaptive selection of human mtDNA haplogroups: an experimental bioenergetics approach

J.L. Elson, D.M. Turnbull and R.W. Taylor..........e3–e5

Published on the Internet 14 May 2007, doi:10.1042/BJ20070524 (see accompanying paper pp. 345–351)

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STAT5 isoforms: controversies and clarifications

H.L. Ramos, J.J. O'Shea and W.T. Watford..........e1–e2

Published on the Internet 26 April 2007, doi:10.1042/BJ20070420 (see accompanying paper pp. 81–87)

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Volume 403

Evolutionary tinkering: birth of a novel chloroplast protein

T. Kleine and D. Leister..........e13–e14

Published on the Internet 12 April 2007, doi:10.1042/BJ20070312 (see accompanying paper pp. 493–499)

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Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways

F. Koumanov and G.D. Holman..........e9–e11

Published on the Internet 26 March 2007, doi:10.1042/BJ20070271 (see accompanying paper pp. 353–358)

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Mitotic phosphorylation: breaking the balance of power by a tactical retreat

R.Y.C. Poon..........e5–e7

Published on the Internet 26 March 2007, doi:10.1042/BJ20070290 (see accompanying paper pp. 235–242)

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Nutrient-responsive mTOR signalling grows on Sterile ground

S.J. Cook and S.J. Morley..........e1–e3

Published on the Internet 13 March 2007, doi:10.1042/BJ20070207 (see accompanying paper pp. 13–20)

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Volume 402

Differential regulation of the Menkes and Wilson disease copper transporters by hormones: an integrated model of metal transport in the placenta

D.R. Richardson and Y. Suryo Rahmanto..........e1–e3

Published on the Internet 12 February 2007, doi:10.1042/BJ20061844 (see accompanying paper pp. 241–250)

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Volume 401

Unusual phyletic distribution of peptidases as a tool for identifying potential drug targets

N.D. Rawlings..........e5–e7

Published on the Internet 21 December 2006, doi:10.1042/BJ20061613

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A sharper instrument for dissecting signalling events: a specific AGC kinase inhibitor

C.G. Proud..........e1–e3

Published on the Internet 11 December 2006, doi:10.1042/BJ20061691

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Volume 400

The case for regulating indispensable amino acid metabolism: the branched-chain a-keto acid dehydrogenase kinase-knockout mouse

S.M. Huston..........e1–e3

Published on the Internet 27 October 2006, doi:10.1042/BJ20061506 (see accompanying paper pp. 153–162)

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Volume 399

Compatible solutes and fungal development

J. Dijksterhuis and R.P. de Vries..........e3–e5

Published on the Internet 27 September 2006, doi:10.1042/BJ20061229 (see accompanying paper pp. 231–239)

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Intricacies and surprises of nuclear–mitochondrial co-evolution

D.K. Willkomm and R.K. Hartmann..........e7–e9

Published on the Internet 27 September 2006, doi:10.1042/BJ20061241 (see accompanying paper pp. 249–256)

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The fructosamine 3-kinase knockout mouse: a tool for testing the glycation hypothesis of intracellular protein damage in diabetes and aging

V.M. Monnier..........e11–e13

Published on the Internet 27 September 2006, doi:10.1042/BJ20061232 (see accompanying paper pp. 257–264)

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Stabilizing daily clock proteins

H.D. Piggins..........e1–e2

Published on the Internet 13 September 2006, doi:10.1042/BJ20061211 (see accompanying paper pp. 169–175)

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Volume 396

HIV Tat-mediated transcriptional regulation of proteasome protein cleavage specificity

C. Aresté and D.J. Blackbourn..........e13–e15

Published on the Internet 15 May 2006, doi:10.1042/BJ20060497 (see accompanying paper pp. 371–380)

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Cleavage, a real turn-off? HIV-mediated proteolysis of PABP1

B. Collier and N.K. Gray..........e9–e11

Published on the Internet 15 May 2006, doi:10.1042/BJ20060545 (see accompanying paper pp. 219–226)

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Sensing inorganic carbon: CO₂ and HCO₃^-

J.A. Raven..........e5–e7

Published on the Internet 15 May 2006, doi:10.1042/BJ20060574 (see accompanying paper pp. 215–218)

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Cardiac ryanodine receptor phosphorylation: target sites and functional consequences

D.M. Bers..........e1–e3

Published on the Internet 26 April 2006, doi:10.1042/BJ20060377 (see accompanying paper pp. 7–16)

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Volume 395

Clustering of heat-shock factors

J.K. Björk and L. Sistonen..........e5–e6

Published on the Internet 15 March 2006, doi:10.1042/BJ20060071 (see accompanying paper pp. 223–231)

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Peptide inhibitors MAP the way towards fighting anthrax pathogenesis

A.M. deCathelineau and G.M. Bokoch..........e1–e3

Published on the Internet 15 March 2006, doi:10.1042/BJ20060245 (see accompanying paper pp. 157–163)

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Volume 394

The ubiquitin-associated domain of AMPK-related kinases allows LKB1-induced phosphorylation and activation

M.H. Rider..........e7–e9

Published on the Internet 24 February 2006, doi:10.1042/BJ20060184 (see accompanying paper pp. 545–555)

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Role of HNF4a in the superinduction of the IL-1b-activated iNOS gene by oxidative stress

F.J. Gonzalez..........e3–e5

Published on the Internet 10 February 2006, doi:10.1042/BJ20060005 (see accompanying paper pp. 379–387)

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New ways to print living cells promise breakthroughs for engineering complex tissues in vitro

G.S. Withers..........e1–e2

Published on the Internet 10 February 2006, doi:10.1042/BJ20060137 (see accompanying paper pp. 375–378)

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Volume 393

Unexpected similarity between the cytosolic West Nile virus NS3 and the secretory furin-like serine proteinases

N.G. Seidah..........e1–e3

Published on the Internet 23 December 2005, doi:10.1042/BJ20051787 (see accompanying paper pp. 503–511)

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Volume 392

Bacterial enzymes that can deglycate glucose- and fructose-modified lysine

V.M. Monnier..........e1–e3

Published on the Internet 22 November 2005, doi:10.1042/BJ20051625 (see accompanying paper pp. 263–269)

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Volume 391

New insights into the families of PLC enzymes: looking back and going forward

M. Katan..........e7–e9

Published on the Internet 25 October 2005, doi:10.1042/BJ20051506 (see accompanying paper pp. 667–676)

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Regulation of mitosis by poly(ADP-ribosyl)ation

D.A. Compton..........e5–e6

Published on the Internet 10 October 2005, doi:10.1042/BJ20051437 (see accompanying paper pp. 177–184)

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WNK lies upstream of kinases involved in regulation of ion transporters

G. Gamba..........e1–e3

Published on the Internet 26 September 2005, doi:10.1042/BJ20051345 (see accompanying paper pp. 17–24)

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Volume 390

Dampening the silencing effect of RNA interference in mammals

J. Zhang..........e5–e6

Published on the Internet 5 September 2005, doi:10.1042/BJ20051206 (see accompanying paper pp. 675–679)

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Slow thrombin in solution

J.A. Huntington..........e1–e3

Published on the Internet 23 August 2005, doi:10.1042/BJ20051099 (see accompanying paper pp. 485–492)

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Volume 388

Spotting new DNA damage-responsive chromatin-binding proteins

B.N. Wardleworth and J.A. Downs..........e1–e2

Published on the Internet 10 May 2005, DOI 10.1042/BJ20050503 (see accompanying paper pp. 7–15)

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Volume 386

Volume 373