In this paper, Christian Lee and colleagues report on the first X-ray crystal structure of the unphosphorylated ALK (anaplastic lymphoma kinase) catalytic domain in the apo, ADP-bound and staurosporine-bound forms at 1.85–2.1 Å resolution, which will enable the rational design of potent and specific ALK inhibitors to treat ALK-derived malignancies.
Terri Attwood and her colleagues in Manchester survey some of the recent projects that have sought to transform scholarly publishing paradigms, culminating in the
Semantic Biochemical Journal.
Download the software and see how papers are richer and the data more accessible than before. The
Semantic Biochemical Journal marks the beginning of a publishing revolution, changing the way we interact with, and review, the scholarly scientific journal forever. Join us as pioneers of the Living Journal.
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