Welcome to the BJ ChemBio knowledge environment!

BJ ChemBio welcomes research whereby chemistry and chemical tools in their broadest sense are used to study and manipulate biological systems. The development of new tools, compounds and reagents to probe biological questions in innovative ways are welcomed. Please note that papers should include an element of biological investigation in order to be considered for this Knowledge Environment.

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	This week's accepted papers - IMPs
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	Latest news - COMMENTARIES novel antibacterial drug targets FtsZ protein anti-trypanosome drug development: a novel approach
	Upcoming MEETINGS Chemical Biology 2010 EMBL Heidelberg, Germany, 22–25 September 2010
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	Community RESOURCES Chemical Biology Consortium Initiative National Centre for Protein Kinase Profiling

A novel assay to assess LRRK2 inhibitor potency

Building on their discovery that Ser⁹¹⁰ and Ser⁹³⁵ are phosphorylated in LRRK2 (leucine-rich repeat protein kinase 2), Dario Alessi, Jeremy Nichols and colleagues show that dephosphorylation of Ser⁹¹⁰/Ser⁹³⁵, disruption of 14-3-3 binding and/or monitoring LRRK2 cytoplasmic localization can be utilized as an assay to assess the relative activity of LRRK2 inhibitors in vivo.

Novel proteasome inhibitors identified for the 20S β5-subunit

In this paper, which is freely available to all readers, Christopher Blackburn, Jonathan Blank and colleagues describe the synthesis, activity and binding mode of a novel series of non-covalent proteasome inhibitors with unprecedented potency and selectivity for the β5 (chymotrypsin-like) site over the β1and β2 sites of the 20S core particle of the proteasome.

Calling International Rescue: knowledge lost in literature and data landslide!

Terri Attwood and her colleagues in Manchester survey some of the recent projects that have sought to transform scholarly publishing paradigms, culminating in the Semantic Biochemical Journal. Download the software and see how papers are richer and the data more accessible than before. The Semantic Biochemical Journal marks the beginning of a publishing revolution, changing the way we interact with, and review, the scholarly scientific journal forever. Join us as pioneers of the Living Journal.

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