Most read Reviews

The most frequently downloaded Reviews for the 12 months to the end of July 2010 are shown below

12162	Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology Sören Beinke and Steven C Ley (2004) 382, 393-409 doi:10.1042/BJ20040544 Abstract | Legacy HTML | Full text PDF
10106	Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway P C Heinrich, I Behrmann, G Müller-Newen, F Schaper and L Graeve (1998) 334, 297-314 Abstract | Legacy HTML | Full text PDF
9372	Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions W Kolch (2000) 351, 289-305 Abstract | Legacy HTML | Full text PDF
8909	Structure, function and regulation of pyruvate carboxylase S Jitrapakdee and J C Wallace (1999) 340, 1-16 Abstract | Legacy HTML | Full text PDF
7571	Chaperonins N A Ranson, H E White and H R Saibil (1998) 333, 233-242 Abstract | Legacy HTML | Full text PDF
7508	Novel molecular approaches to cystic fibrosis gene therapy Tim W R Lee, David A Matthews and G Eric Blair (2005) 387, 1-15 doi:10.1042/BJ20041923 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
7370	Principles of interleukin (IL)-6-type cytokine signalling and its regulation Peter C Heinrich, Iris Behrmann, Serge Haan, Heike M Hermanns, Gerhard Müller-Newen and Fred Schaper (2003) 374, 1-20 doi:10.1042/BJ20030407 Abstract | Legacy HTML | Full text PDF
6818	Nitric oxide synthases: structure, function and inhibition W K Alderton, C E Cooper and R G Knowles (2001) 357, 593-615 Abstract | Legacy HTML | Full text PDF
6509	Effects of nitrogen monoxide and carbon monoxide on molecular and cellular iron metabolism: mirror-image effector molecules that target iron Ralph N Watts, Prem Ponka and Des R Richardson (2003) 369, 429-440 doi:10.1042/BJ20021302 Abstract | Legacy HTML | Full text PDF
5371	Mouse behavioural analysis in systems biology Peter Van Meer and Jacob Raber (2005) 389, 593-610 doi:10.1042/BJ20042023 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
5234	Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation P J Coffer, J Jin and J R Woodgett (1998) 335, 1-13 Abstract | Legacy HTML | Full text PDF
5234	The unique features of glycolytic pathways in Archaea Corné H Verhees, Servé W M Kengen, Judith E Tuininga, Gerrit J Schut, Michael W W Adams, Willem M De Vos and John Van Der Oost (2003) 375, 231-246 doi:10.1042/BJ20021472 Abstract | Legacy HTML | Full text PDF
4759	Sphingosine 1-phosphate signalling in mammalian cells S Pyne and N J Pyne (2000) 349, 385-402 Abstract | Legacy HTML | Full text PDF
4692	Rho GTPases and their effector proteins A L Bishop and A Hall (2000) 348, 241-255 Abstract | Legacy HTML | Full text PDF
4228	Signal transduction by the Wnt family of ligands T C Dale (1998) 329, 209-223 Abstract | Legacy HTML | Full text PDF
3891	Transglutaminases: nature's biological glues Martin Griffin, Rita Casadio and Carlo M Bergamini (2002) 368, 377-396 doi:10.1042/BJ20021234 Abstract | Legacy HTML | Full text PDF
3828	GSK3 takes centre stage more than 20 years after its discovery S Frame and P Cohen (2001) 359, 1-16 Abstract | Legacy HTML | Full text PDF
3825	Arginine metabolism: nitric oxide and beyond G Wu and S M Morris (1998) 336, 1-17 Abstract | Legacy HTML | Full text PDF
3690	Emerging and diverse roles of protein kinase C in immune cell signalling Seng-Lai Tan and Peter J Parker (2003) 376, 545-552 doi:10.1042/BJ20031406 Abstract | Legacy HTML | Full text PDF
3565	Retinoid-binding proteins: mediators of retinoid action N Noy (2000) 348, 481-495 Abstract | Legacy HTML | Full text PDF
3501	Biochemistry and pathology of radical-mediated protein oxidation R T Dean, S Fu, R Stocker and M J Davies (1997) 324, 1-18 Abstract | Legacy HTML | Full text PDF
3458	Histone deacetylases (HDACs): characterization of the classical HDAC family Annemieke J M de Ruijter, Albert H van Gennip, Huib N Caron, Stephan Kemp and André B P van Kuilenburg (2003) 370, 737-749 doi:10.1042/BJ20021321 Abstract | Legacy HTML | Full text PDF
3434	Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors E Hermans and R A Challiss (2001) 359, 465-484 Abstract | Legacy HTML | Full text PDF
3296	PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation Zhou-shen Zhao and Ed Manser (2005) 386, 201-214 doi:10.1042/BJ20041638 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3223	Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling D T Denhardt (1996) 318, 729-747 Abstract | Legacy HTML | Full text PDF
3198	Mechanisms of double strand break repair in somatic mammalian cells Andrea Hartlerode and Ralph Scully (2009) 423, 157-168 doi:10.1042/BJ20090942 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3180	Dual-specificity phosphatases: critical regulators with diverse cellular targets Kate I Patterson, Tilman Brummer, Philippa M O'Brien and Roger J Daly (2009) 418, 475-489 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3114	Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis Guy A Rutter, Gabriela Da Silva Xavier and Isabelle Leclerc (2003) 375, 1-16 doi:10.1042/BJ20030048 Abstract | Legacy HTML | Full text PDF
3058	Recent insights into the structure of Toll like receptors and post translational modifications of their associated signalling proteins Susan Carpenter and LAJ O'Neill (2009) 422, 1-10 doi:10.1042/BJ20090616 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
3037	N-acetylglutamate and its changing role through evolution Ljubica Caldovic and Mendel Tuchman (2003) 372, 279-290 doi:10.1042/BJ20030002 Abstract | Legacy HTML | Full text PDF
3035	The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation Lars P Van Der Heide, Marco F M Hoekman and Marten P Smidt (2004) 380, 297-309 doi:10.1042/BJ20040167 Abstract | Legacy HTML | Full text PDF
2976	The mitochondrial permeability transition pore and its role in cell death M Crompton (1999) 341, 233-249 Abstract | Legacy HTML | Full text PDF
2960	Regulation of serum amyloid A protein expression during the acute-phase response L E Jensen and A S Whitehead (1998) 334, 489-503 Abstract | Legacy HTML | Full text PDF
2939	Structural analyses reveal two distinct families of nucleoside phosphorylases Matthew J Pugmire and Steven E Ealick (2002) 361, 1-25 Abstract | Legacy HTML | Full text PDF
2936	Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes Carol Mackintosh (2004) 381, 329-342 doi:10.1042/BJ20031332 Abstract | Legacy HTML | Full text PDF
2801	Getting into position: the catalytic mechanisms of protein ubiquitylation Lori A Passmore and David Barford (2004) 379, 513-525 doi:10.1042/BJ20040198 Abstract | Legacy HTML | Full text PDF
2796	Carnitine biosynthesis in mammals Frédéric M Vaz and Ronald J A Wanders (2002) 361, 417-429 Abstract | Legacy HTML | Full text PDF
2775	Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily D Sheehan, G Meade, V M Foley and C A Dowd (2001) 360, 1-16 Abstract | Legacy HTML | Full text PDF
2757	Connexin 43 phosphorylation – Structural changes and biological effects Joell Solan and Paul Lampe (2009) 419, 261-272 doi:10.1042/BJ20082319 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2729	The extended protein kinase C superfamily H Mellor and P J Parker (1998) 332, 281-292 Abstract | Legacy HTML | Full text PDF
2637	Polyester synthases: natural catalysts for plastics Bernd H A Rehm (2003) 376, 15-33 doi:10.1042/BJ20031254 Abstract | Legacy HTML | Full text PDF
2565	Caspases: the executioners of apoptosis G M Cohen (1997) 326, 1-16 Abstract | Legacy HTML | Full text PDF
2545	Electrospray and tandem mass spectrometry in biochemistry W J Griffiths, A P Jonsson, S Liu, D K Rai and Y Wang (2001) 355, 545-561 Abstract | Legacy HTML | Full text PDF
2540	Functional architecture in the cell nucleus M Dundr and T Misteli (2001) 356, 297-310 Abstract | Legacy HTML | Full text PDF
2531	Amino acid transporters: roles in amino acid sensing and signalling in animal cells Russell Hyde, Peter M Taylor and Harinder S Hundal (2003) 373, 1-18 Abstract | Legacy HTML | Full text PDF
2529	Collagen fibril formation K E Kadler, D F Holmes, J A Trotter and J A Chapman (1996) 316, 1-11 Abstract | Legacy HTML | Full text PDF
2455	Calling International Rescue: knowledge lost in literature and data landslide! Teresa Attwood, Douglas Kell, Philip McDermott, James Marsh, Steve Pettifer and David Thorne (2009) 424, 317-333 doi:10.1042/BJ20091474 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF
2378	The glucose-6-phosphatase system Emile van Schaftingen and Isabelle Gerin (2002) 362, 513-532 Abstract | Legacy HTML | Full text PDF
2293	Positive and negative regulation of T-cell activation through kinases and phosphatases Tomas Mustelin and Kjetil Taskén (2003) 371, 15-27 doi:10.1042/BJ20021637 Abstract | Legacy HTML | Full text PDF
2293	Anaplastic Lymphoma Kinase: Signaling in development and disease Ruth Palmer, Emma Vernersson, Caroline Grabbe and Bengt Hallberg (2009) 420, 345-361 doi:10.1042/BJ20090387 Abstract | Enhanced Full Text | Legacy HTML | Full text PDF